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Neglected Facts on Mycobacterium Avium Subspecies Paratuberculosis and Type 1 Diabetes.

ABSTRACT: Civilization factors are responsible for the increasing of human exposure to mycobacteria from environment, water, and food during the last few decades. Urbanization, lifestyle changes and new technologies in the animal and plant industry are involved in frequent contact of people with mycobacteria. Type 1 diabetes is a multifactorial polygenic disease; its origin is conditioned by the mutual interaction of genetic and other factors. The environmental factors and certain pathogenetic pathways are shared by some immune mediated chronic inflammatory and autoimmune diseases, which are associated with triggers originating mainly from Mycobacterium avium subspecies paratuberculosis, an intestinal pathogen which persists in the environment. Type 1 diabetes and some other chronic inflammatory diseases thus pose the global health problem which could be mitigated by measures aimed to decrease the human exposure to this neglected zoonotic mycobacterium.

SUBMITTER: Ozana V

PROVIDER: S-EPMC8998319 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Neglected Facts on <i>Mycobacterium Avium</i> Subspecies <i>Paratuberculosis</i> and Type 1 Diabetes.

Ozana Veronika V Hruska Karel K Sechi Leonardo A LA

International journal of molecular sciences 20220326 7

Civilization factors are responsible for the increasing of human exposure to mycobacteria from environment, water, and food during the last few decades. Urbanization, lifestyle changes and new technologies in the animal and plant industry are involved in frequent contact of people with mycobacteria. Type 1 diabetes is a multifactorial polygenic disease; its origin is conditioned by the mutual interaction of genetic and other factors. The environmental factors and certain pathogenetic pathways ar ...[more]

PMID: 35409018

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