Ontology highlight
ABSTRACT:
SUBMITTER: Andrade V
PROVIDER: S-EPMC9007517 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Andrade Virginia V Bai Jian J Gupta-Rossi Neetu N Jimenez Ana Joaquina AJ Delevoye Cédric C Lamaze Christophe C Echard Arnaud A
Science advances 20220413 15
During cytokinesis, the intercellular bridge (ICB) connecting the daughter cells experiences pulling forces, which delay abscission by preventing the assembly of the ESCRT scission machinery. Abscission is thus triggered by tension release, but how ICB tension is controlled is unknown. Here, we report that caveolae, which are known to regulate membrane tension upon mechanical stress in interphase cells, are located at the midbody, at the abscission site, and at the ICB/cell interface in dividing ...[more]