Ontology highlight
ABSTRACT:
SUBMITTER: Bottcher RT
PROVIDER: S-EPMC2683706 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Böttcher Ralph T RT Wiesner Sebastian S Braun Attila A Wimmer Reiner R Berna Alejandro A Elad Nadav N Medalia Ohad O Pfeifer Alexander A Aszódi Attila A Costell Mercedes M Fässler Reinhard R
The EMBO journal 20090305 8
Profilins are key factors for dynamic rearrangements of the actin cytoskeleton. However, the functions of profilins in differentiated mammalian cells are uncertain because profilin deficiency is early embryonic lethal for higher eukaryotes. To examine profilin function in chondrocytes, we disrupted the profilin 1 gene in cartilage (Col2pfn1). Homozygous Col2pfn1 mice develop progressive chondrodysplasia caused by disorganization of the growth plate and defective chondrocyte cytokinesis, indicate ...[more]