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A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4'-Bisfluorophenyl)methoxymethyl group.

ABSTRACT: (4,4'-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved via 2% of TFA in CH₂Cl₂ without affecting the Boc group.

SUBMITTER: Mitachi K

PROVIDER: S-EPMC9009825 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4'-Bisfluorophenyl)methoxymethyl group.

Mitachi Katsuhiko K Mingle David D Kurosu Michio M

Synthesis 20210325 15

(4,4'-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved via 2% of TFA in CH<sub>2</sub>Cl<sub>2</sub> without affecting the Boc group. ...[more]

PMID: 35431351

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