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Estimation of causal quantile effects with a binary instrumental variable and censored data.

ABSTRACT: The causal effect of a treatment is of fundamental interest in the social, biological, and health sciences. Instrumental variable (IV) methods are commonly used to determine causal treatment effects in the presence of unmeasured confounding. In this work, we study a new binary IV framework with randomly censored outcomes where we propose to quantify the causal treatment effect by the concept of complier quantile causal effect (CQCE). The CQCE is identifiable under weaker conditions than the complier average causal effect when outcomes are subject to censoring, and it can provide useful insight into the dynamics of the causal treatment effect. Employing the special characteristic of the binary IV and adapting the principle of conditional score, we uncover a simple weighting scheme that can be incorporated into the standard censored quantile regression procedure to estimate CQCE. We develop robust nonparametric estimation of the derived weights in the first stage, which permits stable implementation of the second stage estimation based on existing software. We establish rigorous asymptotic properties for the proposed estimator, and confirm its validity and satisfactory finite-sample performance via extensive simulations. The proposed method is applied to a bone marrow transplant dataset to evaluate the causal effect of rituximab in diffuse large B-cell lymphoma patients.

SUBMITTER: Wei B

PROVIDER: S-EPMC9015211 | biostudies-literature |

REPOSITORIES: biostudies-literature

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