Ontology highlight
ABSTRACT:
SUBMITTER: Wen ZH
PROVIDER: S-EPMC9017157 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Wen Zi-Hang ZH Langsam Jeremy L JL Zhang Lu L Shen Wenjun W Zhou Xin X
Cell reports methods 20211220 1
Single-cell RNA sequencing (scRNA-seq) offers opportunities to study gene expression of tens of thousands of single cells simultaneously, to investigate cell-to-cell variation, and to reconstruct cell-type-specific gene regulatory networks. Recovering dropout events in a sparse gene expression matrix for scRNA-seq data is a long-standing matrix completion problem. In this article, we introduce Bfimpute, a Bayesian factorization imputation algorithm that reconstructs two latent gene and cell matr ...[more]