Ontology highlight
ABSTRACT:
SUBMITTER: Hu MW
PROVIDER: S-EPMC6742414 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Hu Ming-Wen MW Kim Dong Won DW Liu Sheng S Zack Donald J DJ Blackshaw Seth S Qian Jiang J
PLoS computational biology 20190830 8
Single-cell RNA-sequencing (scRNA-seq) provides new opportunities to gain a mechanistic understanding of many biological processes. Current approaches for single cell clustering are often sensitive to the input parameters and have difficulty dealing with cell types with different densities. Here, we present Panoramic View (PanoView), an iterative method integrated with a novel density-based clustering, Ordering Local Maximum by Convex hull (OLMC), that uses a heuristic approach to estimate the r ...[more]