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A flexible robust model for blood supply chain network design problem.

ABSTRACT: World Health Organization (WHO) declared COVID-19 as a pandemic On March 12, 2020. Up to January 13, 2022, 320,944,953 cases of infection and 5,539,160 deaths have been reported worldwide. COVID-19 has negatively impacted the blood supply chain by drastically reducing blood donation. Therefore, developing models to design effective blood supply chains in emergencies is essential. This research offers a novel multi-objective Transportation-Location-Inventory-Routing (TLIR) formulation for an emergency blood supply chain network design problem. We answer questions regarding strategic, operational, and tactical decisions considering disruption in the network and blood shelf-life. Since, in real-world applications, the parameters of the proposed mathematical formulation are uncertain, two flexible uncertain models are proposed to provide risk-averse and robust solutions for the problem. We applied the proposed formulations in a case study. Under various scenarios and realizations, we show that the offered robust model handles uncertainties more efficiently and finds solutions that have significantly lower costs and delivery time. To make a reliable conclusion, we performed extensive worst-case analyses to demonstrate the robustness of the results. In the end, we provide critical managerial insights to enhance the effectiveness of the supply chain.

Supplementary information

The online version contains supplementary material available at 10.1007/s10479-022-04673-9.

SUBMITTER: Khalilpourazari S

PROVIDER: S-EPMC9022900 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:In this paper, we study the topological properties of the global supply chain network in terms of its degree distribution, clustering coefficient, degree-degree correlation, bow-tie structure, and community structure to test the efficient supply chain propositions proposed by E. J.S. Hearnshaw et al. The global supply chain data in the year 2017 are constructed by collecting various company data from the web site of Standard & Poor's Capital IQ platform. The in- and out-degree distributions are characterized by a power law of the form of γin = 2.42 and γout = 2.11. The clustering coefficient decays [Formula: see text] with an exponent βk = 0.46. The nodal degree-degree correlations 〈knn(k)〉 indicates the absence of assortativity. The bow-tie structure of giant weakly connected component (GWCC) reveals that the OUT component is the largest and consists 41.1% of all firms. The giant strong connected component (GSCC) is comprised of 16.4% of all firms. We observe that upstream or downstream firms are located a few steps away from the GSCC. Furthermore, we uncover the community structures of the network and characterize them according to their location and industry classification. We observe that the largest community consists of the consumer discretionary sector based mainly in the United States (US). These firms belong to the OUT component in the bow-tie structure of the global supply chain network. Finally, we confirm the validity of Hearnshaw et al.'s efficient supply chain propositions, namely Proposition S1 (short path length), Proposition S2 (power-law degree distribution), Proposition S3 (high clustering coefficient), Proposition S4 ("fit-gets-richer" growth mechanism), Proposition S5 (truncation of power-law degree distribution), and Proposition S7 (community structure with overlapping boundaries) regarding the global supply chain network. While the original propositions S1 just mentioned a short path length, we found the short path from the GSCC to IN and OUT by analyzing the bow-tie structure. Therefore, the short path length in the bow-tie structure is a conceptual addition to the original propositions of Hearnshaw.

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A flexible robust model for blood supply chain network design problem.

Supplementary information

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