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A facile method for Rh-catalyzed decarbonylative ortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids.

ABSTRACT: A facile and effective method for Rh-catalyzed direct ortho-alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.

SUBMITTER: Tian Y

PROVIDER: S-EPMC9033830 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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A facile method for Rh-catalyzed decarbonylative ortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids.

Tian Yiqiang Y Liu Xiaojie X He Bangyue B Ren Yuxi Y Su Weiping W

RSC advances 20210501 32

A facile and effective method for Rh-catalyzed direct ortho-alkylation of C-H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as f ...[more]

PMID: 35479217

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