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Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system.

ABSTRACT: An operationally rapid and efficient synthesis of N-sulfonyl formamidines that proceeds under mild conditions was achieved by reaction of a mixture of an amine, a sulfonyl azide, and a terminal ynone under catalyst-free and solvent-free conditions. Terminal ynones provide the C source to formamidines via complete cleavage of C[triple bond, length as m-dash]C.

SUBMITTER: Zhou Z

PROVIDER: S-EPMC9042323 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system.

Zhou Zitong Z Zhao Yu Y Zhou Donghua D Li Li L Luo Hui H Cui Liao L Yang Weiguang W

RSC advances 20211018 54

An operationally rapid and efficient synthesis of N-sulfonyl formamidines that proceeds under mild conditions was achieved by reaction of a mixture of an amine, a sulfonyl azide, and a terminal ynone under catalyst-free and solvent-free conditions. Terminal ynones provide the C source to formamidines via complete cleavage of C[triple bond, length as m-dash]C. ...[more]

PMID: 35497291

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