Highly sensitive non-enzymatic hydrogen peroxide monitoring platform based on nanoporous gold via a modified solid-phase reaction method.
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ABSTRACT: In this work, nanoporous gold (NPG) fabricated using a modified solid-phase reaction method was developed as an electrocatalyst for the nonenzymatic detection of hydrogen peroxide (H2O2). The NPG morphology and structure were characterized by scanning electron microscopy and high-resolution transmission electron microscopy. The fabricated NPG exhibited a nanoporous framework with numerous structural defects. The NPG-based amperometric H2O2 sensor had a good selectivity, reproducibility, and low detection limit (0.3 μM) under near physiological conditions (pH = 7.4). The sensitivities of this sensor over concentration ranges of 0.002-5 mM and 5-37.5 mM were 159 and 64 μA mM-1 cm-2, respectively. These results indicate that the developed NPG is a promising material for the electrochemical sensing of H2O2.
SUBMITTER: Yang Z
PROVIDER: S-EPMC9043567 | biostudies-literature |
REPOSITORIES: biostudies-literature
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