Unknown

Dataset Information

0

A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolines via selective multiple C-C bond formation under metal-free conditions.

ABSTRACT: A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1'H-spiro[pyrazolo[4,3-f]quinoline-8,5'-pyrimidine]-2',4',6'(3'H)-triones (d.r. up to 20 : 1 (syn : anti)) and tetrahydro-8H-pyrazolo[4,3-f]pyrimido[4,5-b]quinoline-8,10(9H)-diones via formation of selective multiple C-C bonds under identical reaction conditions (viz. ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds.

SUBMITTER: Patel DM 

PROVIDER: S-EPMC9054100 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-<i>f</i>]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3-<i>f</i>]pyrimido[4,5-<i>b</i>]quinolines <i>via</i> selective multiple C-C bond formation under metal-free conditions.

Patel Divyang M DM   Patel Hetal J HJ   Padrón José M JM   Patel Hitendra M HM  

RSC advances 20200522 33

A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1'<i>H</i>-spiro[pyrazolo[4,3-<i>f</i>]quinoline-8,5'-pyrimidine]-2',4',6'(3'<i>H</i>)-triones (d.r. up to 20 : 1 (<i>syn</i> : <i>anti</i>)) and tetrahydro-8<i>H</i>-pyrazolo[4,3-<i>f</i>]pyrimido[4,5-<i>b</i>]quinoline-8,10(9<i>H</i>)-diones <i>via</i> formation of selective multiple C-C bonds under identical reaction conditions (<i>viz.</i> ethanol as a reaction medium an  ...[more]

Similar Datasets

Unknown 3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.
| S-EPMC5972072 | biostudies-literature
Unknown One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines.
| S-EPMC1470455 | biostudies-literature
Unknown HSD1787, a Tetrahydro-3<i>H</i>-Pyrazolo[4,3-<i>f</i>]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations.
| S-EPMC7513343 | biostudies-literature
Unknown Discovery of Pyrazolo[4,3-c]quinolines Derivatives as Potential Anti-Inflammatory Agents through Inhibiting of NO Production.
| S-EPMC6102577 | biostudies-literature
Unknown Design and synthesis of novel pyrazolo[4,3-<i>d</i>]pyrimidines as potential therapeutic agents for acute lung injury.
| S-EPMC6534230 | biostudies-literature
Unknown Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-<i>f</i>]quinoline Derivatives.
| S-EPMC9026320 | biostudies-literature
Unknown (4S)-3-Methyl-5,6,7,8-tetra-hydro-4H-spiro-[[1,2]oxazolo[5,4-b]quinoline-4,3'-indole]-2',5-dione.
| S-EPMC3998324 | biostudies-literature
Unknown Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions.
| S-EPMC6278517 | biostudies-literature
Unknown (4S)-5'-Chloro-3,7,7-trimethyl-5,6,7,8-tetra-hydro-4H-spiro-[1,2-oxazolo[5,4-b]quinoline-4,3'-indole]-2',5-dione.
| S-EPMC3998327 | biostudies-literature
Unknown One-pot phosphine-catalyzed syntheses of quinolines.
| S-EPMC3459651 | biostudies-literature