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Iron-catalyzed tandem reaction of C-Se bond coupling/selenosulfonation of indols with benzeneselenols.

ABSTRACT: An iron-catalyzed tandem reaction of C-Se bond coupling/selenosulfonation was developed. Starting from sample indols and benzeneselenols versatile biologically active 2-benzeneselenonyl-1H-indoles derivatives were efficiently synthesized. The reaction mechanism was studied by the deuterium isotope study and in situ ESI-MS experiments. This protocol features mild reaction conditions, wider substrate scope and provides an economical approach toward C(sp²)-Se bond formation.

SUBMITTER: Guan S

PROVIDER: S-EPMC9055526 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Iron-catalyzed tandem reaction of C-Se bond coupling/selenosulfonation of indols with benzeneselenols.

Guan Senling S Chen Yue Y Wu Hongjie H Xu Runsheng R

RSC advances 20200720 45

An iron-catalyzed tandem reaction of C-Se bond coupling/selenosulfonation was developed. Starting from sample indols and benzeneselenols versatile biologically active 2-benzeneselenonyl-1H-indoles derivatives were efficiently synthesized. The reaction mechanism was studied by the deuterium isotope study and in situ ESI-MS experiments. This protocol features mild reaction conditions, wider substrate scope and provides an economical approach toward C(sp2)-Se bond formation ...[more]

PMID: 35515762

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