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Molecular pathogenesis and systemic therapies for hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to the advent of effective systemic therapies. Here we discuss the molecular pathogenesis of HCC, molecular classes and determinants of heterogeneity. In addition, effective single-agent and combination systemic therapies involving immunotherapies as standard of care are analyzed. Finally, we propose a flowchart of sequential therapies, explore mechanisms of resistance and address the need for predictive biomarkers.

SUBMITTER: Llovet JM

PROVIDER: S-EPMC9060366 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Molecular pathogenesis and systemic therapies for hepatocellular carcinoma.

Llovet Josep M JM Pinyol Roser R Kelley Robin K RK El-Khoueiry Anthony A Reeves Helen L HL Wang Xin Wei XW Gores Gregory J GJ Villanueva Augusto A

Nature cancer 20220428 4

Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to the advent of effective systemic therapies. Here we discuss the molecular pathogenesis of HCC, molecular classes and determinants of heterogeneity. In addition, effective single-agent and combination systemic therapies involving immunotherapies as standard of care are analyzed. Finally, we propose a flowchart of sequential therapies, explore ...[more]

PMID: 35484418

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Recent Advances in Systemic Therapies for Advanced Hepatocellular Carcinoma.

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