Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
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ABSTRACT:
SUBMITTER: Marechal N
PROVIDER: S-EPMC9061844 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Marechal Nils N Serrano Banyuhay P BP Zhang Xinyan X Weitz Charles J CJ
Nature communications 20220502 1
Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid hormones have been assigned within the structure of human TG, but the process of hormone formation is poorly understood. Here we report a ~3.3-Å cryo-EM structure of native bovine TG with nascent thyro ...[more]
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