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A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters from chromone and isatin.

ABSTRACT: A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters has been developed through an AlCl₃-catalyzed reaction of easily available Baylis-Hillman adducts from chromones and isatin-derivatives. This reaction involves esterification, cyclization and ring opening in a one-step process, and provides an efficient approach for easy access to a series of valuable salicyloylquinoline derivatives with high yields. Moreover, this protocol offers several advantages, such as availability of starting materials, economic availability, operational simplicity and mild reaction conditions.

SUBMITTER: Wang X

PROVIDER: S-EPMC9075531 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters from chromone and isatin.

Wang Xuequan X Yang Zhixin Z Miu Weihang W Ye Pingting P Bai Mengjiao M Duan Suyue S Shen Xianfu X

RSC advances 20191112 63

A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters has been developed through an AlCl<sub>3</sub>-catalyzed reaction of easily available Baylis-Hillman adducts from chromones and isatin-derivatives. This reaction involves esterification, cyclization and ring opening in a one-step process, and provides an efficient approach for easy access to a series of valuable salicyloylquinoline derivatives with high yields. Moreover, this protocol offers several advantages, such a ...[more]

PMID: 35539051

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