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Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems.

ABSTRACT: Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.

SUBMITTER: Ma L 

PROVIDER: S-EPMC9081192 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems.

Ma Luoyang L   Zheng Xiaoyan X   Lin Rui R   Sun Antonia RuJia AR   Song Jintong J   Ye Zhiqiang Z   Liang Dahong D   Zhang Min M   Tian Jia J   Zhou Xin X   Cui Liao L   Liu Yuyu Y   Liu Yanzhi Y  

Drug design, development and therapy 20220504

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the c  ...[more]

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