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A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells.

ABSTRACT: A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change.

SUBMITTER: Zhang P

PROVIDER: S-EPMC9085528 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells.

Zhang Ping P Lv Huaying H Duan Guiyun G Dong Jian J Ge Yanqing Y

RSC advances 20180831 54

A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change. ...[more]

PMID: 35548712

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