Dataset Information

Extra-Neural Metastases From Primary Intracranial Ependymomas: A Systematic Review.

ABSTRACT:

Background

Primary intracranial ependymomas (IE) are rare brain tumors rarely metastasizing outside the central nervous system. We systematically reviewed the literature on extra-neural metastases from primary IEs.

Methods

PubMed, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of extra-neural metastases from primary IEs. Clinical features, management strategies, and survival were analyzed.

Results

We collected 48 patients from 43 studies. Median age was 13 years (range, 2-65). Primary IEs were frequently located in the parietal (22.9%) and frontal (16.7%) lobes, and mostly treated with resection (95.8%) and/or radiotherapy (62.5%). Most IEs were of grade-III (79.1%), and few of grade-I (6.3%) or grade-II (14.6%). 45 patients experienced intracranial recurrences, mostly treated with resection (86.7%), radiotherapy (60%), and/or chemotherapy (24.4%). Median time-interval from primary IEs was 28 months (range, 0-140). Most extra-neural metastases were diagnosed at imaging (37.5%) or autopsy (35.4%). Extra-neural metastases were multifocal in 38 patients (79.1%), mostly involving cervical or hilar lymph-nodes (66.7%), lung/pleura (47.9%), and/or scalp (29.1%). Surgical resection (31.3%), chemotherapy (31.3%) and locoregional radiotherapy (18.8%) were the most common treatments for extra-neural metastases, but 28 (58.3%) patients were not treated. At last follow-up, 37 patients died with median overall-survivals from primary IEs of 36 months (range, 1-239), and from extra-neural metastases of 3 months (range, 0.1-36). Overall-survival was significantly longer in patients with grade-I and II IEs (P=0.040).

Conclusion

Extra-neural metastases from primary IEs are rare, but mostly occur at later disease stages. Multidisciplinary management strategies should be intended mostly for palliation.

SUBMITTER: Palmisciano P

PROVIDER: S-EPMC9093681 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Extra-Neural Metastases From Primary Intracranial Ependymomas: A Systematic Review.

Palmisciano Paolo P Ferini Gianluca G Barone Fabio F Chavda Vishal V Romano Fabrizio F Amico Paolo P Emmanuele Donatella D Nicoletti Giovanni F GF Pompili Gianluca G Giammalva Giuseppe Roberto GR Maugeri Rosario R Iacopino Domenico Gerardo DG Strigari Lidia L Yeo Tseng T TT Cicero Salvatore S Scalia Gianluca G Umana Giuseppe Emmanuele GE

Frontiers in oncology 20220427

<h4>Background</h4>Primary intracranial ependymomas (IE) are rare brain tumors rarely metastasizing outside the central nervous system. We systematically reviewed the literature on extra-neural metastases from primary IEs.<h4>Methods</h4>PubMed, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of extra-neural metastases from primary IEs. Clinical features, management strategies, and survival were analyzed.<h4>Results</h4>We collected 48 patien ...[more]

PMID: 35574408

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Dataset Information

Extra-Neural Metastases From Primary Intracranial Ependymomas: A Systematic Review.

Background

Methods

Results

Conclusion

Publications

Extra-Neural Metastases From Primary Intracranial Ependymomas: A Systematic Review.

Similar Datasets

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