Ontology highlight
ABSTRACT:
SUBMITTER: Mattox AK
PROVIDER: S-EPMC9094745 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Mattox Austin K AK Douville Christopher C Silliman Natalie N Ptak Janine J Dobbyn Lisa L Schaefer Joy J Popoli Maria M Blair Cherie C Judge Kathy K Pollard Kai K Pratilas Christine C Blakeley Jaishri J Rodriguez Fausto F Papadopoulos Nickolas N Belzberg Allan A Bettegowda Chetan C
eLife 20220304
Malignant peripheral nerve sheath tumors (MPNST) are the deadliest cancer that arises in individuals diagnosed with neurofibromatosis and account for nearly 5% of the 15,000 soft tissue sarcomas diagnosed in the United States each year. Comprised of neoplastic Schwann cells, primary risk factors for developing MPNST include existing plexiform neurofibromas (PN), prior radiotherapy treatment, and expansive germline mutations involving the entire <i>NF1</i> gene and surrounding genes. PN develop i ...[more]