Ontology highlight
ABSTRACT:
SUBMITTER: Wegmann S
PROVIDER: S-EPMC9098123 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Wegmann Sabrina S Meister Cindy C Renz Christian C Yakoub George G Wollscheid Hans-Peter HP Takahashi Diane T DT Mikicic Ivan I Beli Petra P Ulrich Helle D HD
Molecular cell 20220308 8
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is often poorly understood because of our inability to control or manipulate this parameter in vivo. Here, we present a strategy for reprogramming polyubiquitin chain linkage by means of tailor-made, linkage- and substrate-selective ubiquitin ligases. Using the polyubiquitylation of the budding yeast replica ...[more]