Ontology highlight
ABSTRACT:
SUBMITTER: Kakarla M
PROVIDER: S-EPMC9102363 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Kakarla Mamatha M ChallaSivaKanaka Sathyavathi S Dufficy Mary F MF Gil Victoria V Filipovich Yana Y Vickman Renee R Crawford Susan E SE Hayward Simon W SW Franco Omar E OE
Cancers 20220509 9
Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor interactions with Ephrin ligands lead to bidirectional signals in the recipient and effector cells. The consequences of continuous reverse Ephrin signaling activation in fibroblasts on prostate cancer (PCa) is unknown. When compared to benign pr ...[more]