Dataset Information

Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.

ABSTRACT:

Background

Meteorological factors and air pollutants have been reported to be associated with hand, foot, and mouth disease (HFMD) epidemics before the introduction of vaccine. However, there is limited evidence for studies with long-term dimensions.

Methods

We collected the daily HFMD counts, weather and air pollution data from 2014 to 2020 in Chengdu. Distributed lag non-linear models (DLNM) were used to assess the associations of meteorological factors and air pollutants on HFMD cases.

Results

From 2014-2020, high relative humidity and precipitation and extremely high and low levels of PM₁₀, O₃, SO₂ and CO increased the risk of HFMD. In pre-vaccination period, extreme high and low temperatures, PM₁₀ and NO₂, low precipitation and high concentrations of PM_2.5 and O₃ significantly increase the risk of HFMD; In post-vaccination period, high relative humidity and low level of CO can significantly increase the incidence of HFMD; During the period of COVID-19, only low temperature will significantly increase the risk of HFMD; Low concentration of air pollutants has the greatest impact on the 6-14 age group, while the high concentration of air pollutants has the greatest impact on the 0-1 age group.

Conclusions

Our study suggest that high relative humidity and precipitation and extremely high and low levels of PM₁₀, O₃, SO₂ and CO increased the risk of HFMD from 2014 to 2020. The results of this study provide a reference for local authorities to formulate intervention measures and establish an environment-based disease early warning system.

SUBMITTER: Peng H

PROVIDER: S-EPMC9112249 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.

Peng Hongxia H Chen Zhenhua Z Cai Lin L Liao Juan J Zheng Ke K Li Shuo S Ren Xueling X Duan Xiaoxia X Tang Xueqin X Wang Xiao X Long Lu L Yang Chunxia C

BMC public health 20220517 1

<h4>Background</h4>Meteorological factors and air pollutants have been reported to be associated with hand, foot, and mouth disease (HFMD) epidemics before the introduction of vaccine. However, there is limited evidence for studies with long-term dimensions.<h4>Methods</h4>We collected the daily HFMD counts, weather and air pollution data from 2014 to 2020 in Chengdu. Distributed lag non-linear models (DLNM) were used to assess the associations of meteorological factors and air pollutants on HFM ...[more]

PMID: 35581574

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Project description:ObjectivesHand, foot, and mouth disease (HFMD) is a viral infectious disease that poses a substantial threat in the Asia-Pacific region. It is widely reported that meteorological factors are associated with HFMD. However, the relationships between air pollutants and HFMD are still controversial. In addition, the interactive effects between meteorological factors and air pollutants on HFMD remain unknown. To fill this research gap, we conducted a time-series study.DesignA time-series study.Setting and participantsDaily cases of HFMD as well as meteorological and air pollution data were collected in Chengdu from 2011 to 2017. A total of 184 610 HFMD cases under the age of 15 were included in our study.Outcome measuresDistributed lag nonlinear models were used to investigate the relationships between HFMD and environmental factors, including mean temperature, relative humidity, SO2, NO2, and PM10. Then, the relative excess risk due to interaction (RERI) and the proportion attributable to interaction were calculated to quantitatively evaluate the interactions between meteorological factors and air pollutants on HFMD. Bivariate response surface models were used to visually display the interactive effects.ResultsThe cumulative exposure-response curves of SO2 and NO2 were inverted 'V'-shaped and 'M'-shaped, respectively, and the risk of HFMD gradually decreased with increasing PM10 concentrations. We found that there were synergistic interactions between mean temperature and SO2, relative humidity and SO2, as well as relative humidity and PM10 on HFMD, with individual RERIs of 0.334 (95% CI 0.119 to 0.548), 0.428 (95% CI 0.214 to 0.642) and 0.501 (95% CI 0.262 to 0.741), respectively, indicating that the effects of SO2 and PM10 on HFMD were stronger under high temperature (>17.3°C) or high humidity (>80.0%) conditions.ConclusionsThere were interactive effects between meteorological factors and air pollutants on HFMD. Our findings could provide guidance for targeted and timely preventive and control measures for HFMD.

Dataset Information

Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.

Background

Methods

Results

Conclusions

Publications

Relationship between meteorological factors, air pollutants and hand, foot and mouth disease from 2014 to 2020.

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