Dataset Information

Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen visual discrimination test in rats.

ABSTRACT: The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study has investigated them from the cognitive aspect yet. As voluntary goal-directed movements induce the desynchronization of mu rhythm, we aimed at exploring whether the response-related brain activity during the touchscreen visual discrimination (VD) task is suitable to detect sensorimotor rhythms and their change under cognitive impairment. Different doses of scopolamine or MK-801 were injected subcutaneously to rats, and epidural electroencephalogram (EEG) was recorded during task performance. Arciform ~ 10 Hz oscillations appeared during visual processing, then two characteristic alpha/beta desynchronization-resynchronization patterns emerged mainly above the sensorimotor areas, serving presumably different motor functions. Beyond causing cognitive impairment, both drugs supressed the touch-related upper alpha (10-15 Hz) reactivity for desynchronization. Reaction time predominantly correlated positively with movement-related alpha and beta power both in normal and impaired conditions. These results support the existence of a mu homologue rodent rhythm whose upper alpha component appeared to be modulated by cholinergic and glutamatergic mechanisms and its power change might indicate a potential EEG correlate of processing speed. The VD task can be utilized for the investigation of sensorimotor rhythms in rats.

SUBMITTER: Kostyalik D

PROVIDER: S-EPMC9114334 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen visual discrimination test in rats.

Kostyalik Diána D Kelemen Kristóf K Lendvai Balázs B Hernádi István I Román Viktor V Lévay György G

Scientific reports 20220517 1

The human mu rhythm has been suggested to represent an important function in information processing. Rodent homologue rhythms have been assumed though no study has investigated them from the cognitive aspect yet. As voluntary goal-directed movements induce the desynchronization of mu rhythm, we aimed at exploring whether the response-related brain activity during the touchscreen visual discrimination (VD) task is suitable to detect sensorimotor rhythms and their change under cognitive impairment ...[more]

PMID: 35581280

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Project description:Brain-computer interfaces (BCI) can be designed with several feedback modalities. To promote appropriate brain plasticity in therapeutic applications, the feedback should guide the user to elicit the desired brain activity and preferably be similar to the imagined action. In this study, we employed magnetoencephalography (MEG) to measure neurophysiological changes in healthy subjects performing motor imagery (MI) -based BCI training with two different feedback modalities. The MI-BCI task used in this study lasted 40-60 min and involved imagery of right- or left-hand movements. 8 subjects performed the task with visual and 14 subjects with proprioceptive feedback. We analysed power changes across the session at multiple frequencies in the range of 4-40 Hz with a generalized linear model to find those frequencies at which the power increased significantly during training. In addition, the power increase was analysed for each gradiometer, separately for alpha (8-13 Hz), beta (14-30 Hz) and gamma (30-40 Hz) bands, to find channels showing significant linear power increase over the session. These analyses were applied during three different conditions: rest, preparation, and MI. Visual feedback enhanced the amplitude of mainly high beta and gamma bands (24-40 Hz) in all conditions in occipital and left temporal channels. During proprioceptive feedback, in contrast, power increased mainly in alpha and beta bands. The alpha-band enhancement was found in multiple parietal, occipital, and temporal channels in all conditions, whereas the beta-band increase occurred during rest and preparation mainly in the parieto-occipital region and during MI in the parietal channels above hand motor regions. Our results show that BCI training with proprioceptive feedback increases the power of sensorimotor rhythms in the motor cortex, whereas visual feedback causes mainly a gamma-band increase in the visual cortex. MI-BCIs should involve proprioceptive feedback to facilitate plasticity in the motor cortex.

Dataset Information

Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen visual discrimination test in rats.

Publications

Response-related sensorimotor rhythms under scopolamine and MK-801 exposures in the touchscreen visual discrimination test in rats.

Similar Datasets

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