Ontology highlight
ABSTRACT:
SUBMITTER: Philippe C
PROVIDER: S-EPMC9120153 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Philippe Cécile C Morency Carlee C Plante Pier-Luc PL Zufferey Edwige E Achigar Rodrigo R Tremblay Denise M DM Rousseau Geneviève M GM Goulet Adeline A Moineau Sylvain S
Nature communications 20220519 1
CRISPR-Cas systems in prokaryotic cells provide an adaptive immunity against invading nucleic acids. For example, phage infection leads to addition of new immunity (spacer acquisition) and DNA cleavage (interference) in the bacterial model species Streptococcus thermophilus, which primarily relies on Cas9-containing CRISPR-Cas systems. Phages can counteract this defense system through mutations in the targeted protospacers or by encoding anti-CRISPR proteins (ACRs) that block Cas9 interference a ...[more]