Ontology highlight
ABSTRACT:
SUBMITTER: Favuzzi E
PROVIDER: S-EPMC9122259 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Favuzzi Emilia E Huang Shuhan S Saldi Giuseppe A GA Binan Loïc L Ibrahim Leena A LA Fernández-Otero Marian M Cao Yuqing Y Zeine Ayman A Sefah Adwoa A Zheng Karen K Xu Qing Q Khlestova Elizaveta E Farhi Samouil L SL Bonneau Richard R Datta Sandeep Robert SR Stevens Beth B Fishell Gord G
Cell 20210706 15
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that GABA-receptive microglia selectively interact with inhibitory cortical synapses during a critical window of mouse postnatal development. GABA initiates a transcriptional synapse remodeling program within these specialized microg ...[more]