Dataset Information

Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3.

ABSTRACT:

Background

The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.

Methods

This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Two distinct groups were constructed according to the epidemiological data: first wave and second wave. The severity of patients admitted was estimated using the SAPS 3 score.

Results

A total of 767 patients were included: 290 were enrolled in the first wave and 477 in the second wave. Patients in the first wave had more comorbidities, were put on mechanical ventilation and required dialysis and vasopressors more frequently (p<0.05). During the second wave, non-invasive ventilation was more often required (p<0.05). In both periods, older patients and higher SAPS 3 scores on admission were associated with death (p<0.05). Non-invasive ventilation use showed a negative association with death only in the second wave period. In the first wave, the SAPS 3 score was more useful (area under the curve [AUC] 0.897) in predicting death in critically ill COVID-19 patients than in the second wave (AUC 0.810).

Conclusion

The SAPS 3 showed very reliable predictive values for death during the waves of the COVID-19 pandemic, mostly together with kidney and pulmonary dysfunction.

SUBMITTER: Lazaro APP

PROVIDER: S-EPMC9129229 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3.

Lázaro Ana Paula Pires APP Albuquerque Polianna Lemos Moura Moreira PLMM Meneses Gdayllon Cavalcante GC Zaranza Marza de Sousa MS Batista Ana Beatriz AB Aragão Natalia Linhares Ponte NLP Beliero Andrea Mazza AM Guimarães Álvaro Rolim ÁR Aragão Nilcyeli Linhares NL Leitão Alessandra Marjorye Maia AMM de Carvalho Marcelo Costa Freire MCF Cavalcante Maria Isabel de Alencar MIA Mota Fabio Augusto Xerez FAX Daher Elizabeth De Francesco EF Martins Alice Maria Costa AMC da Silva Junior Geraldo Bezerra GB

Transactions of the Royal Society of Tropical Medicine and Hygiene 20221101 11

<h4>Background</h4>The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.<h4>Methods</h4>This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Two distinct groups were constructed according to the epidemiological d ...[more]

PMID: 35598042

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Dataset Information

Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3.

Background

Methods

Results

Conclusion

Publications

Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3.

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