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CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.

ABSTRACT: Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments.

SUBMITTER: Todorovic Z

PROVIDER: S-EPMC9139644 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.

Todorovic Zeljko Z Todorovic Dusan D Markovic Vladimir V Ladjevac Nevena N Zdravkovic Natasa N Djurdjevic Predrag P Arsenijevic Nebojsa N Milovanovic Marija M Arsenijevic Aleksandar A Milovanovic Jelena J

Current oncology (Toronto, Ont.) 20220518 5

Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments. ...[more]

PMID: 35621683

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