Unknown

Dataset Information

0

Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia.


ABSTRACT: Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited, the proportion of remissions reached in this disease is clearly the lowest from the spectrum of B-cell tumors. In this review, we discuss the antigenic targets exploited in CLL CAR-T therapy, the determinants of favorable responses, as well as the mechanisms of treatment failure specific to this disease.

SUBMITTER: Mancikova V 

PROVIDER: S-EPMC8197365 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9139644 | biostudies-literature
| S-EPMC10107371 | biostudies-literature
| S-EPMC8996890 | biostudies-literature
| S-EPMC6117613 | biostudies-literature
| S-EPMC9806442 | biostudies-literature
| S-EPMC11366826 | biostudies-literature
| S-EPMC7326110 | biostudies-literature
| S-EPMC8074228 | biostudies-literature
| S-EPMC6247712 | biostudies-literature
| S-EPMC8447616 | biostudies-literature