Dataset Information

Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States.

ABSTRACT:

Background

Multiple sclerosis (MS) has been associated with increased mortality ratios, but few studies have investigated the independent association of MS with mortality.

Objective

To examine the prospective association of MS with risk of mortality in a nationally representative sample of U.S. adults.

Methods

This prospective study included 23,053 adults aged 45-79 years who participated in the National Health Interview Survey in 2002 and 2008. Physician-diagnosed MS was reported by participants during household interviews. These participants were linked to death records from survey date through December 31, 2015.

Results

Among the 23,053 participants included in this study, 120 reported a physician's diagnosis of MS, with a higher prevalence in females (0.85%) than in males (0.31%). During on average 9.4 years (maximum 13.8 years) of observation, 4208 deaths occurred. After adjustment for age, sex, race/ethnicity, socioeconomic factors, lifestyle factors, and BMI, participants with MS had an 80% higher risk of mortality (HR 1.80; 95% CI, 1.11-2.92), compared with those without MS. The association remained significant (HR 1.75; 95% CI, 1.07-2.87) after further adjustment for baseline diabetes, cardiovascular disease, chronic lung disease, and cancer.

Conclusion

In this nationally representative sample of U.S. adults, MS was associated with an increased risk of mortality.

SUBMITTER: Titcomb TJ

PROVIDER: S-EPMC9158421 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature

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Publications

Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States.

Titcomb Tyler J TJ Bao Wei W Du Yang Y Liu Buyun B Snetselaar Linda G LG Wahls Terry L TL

Multiple sclerosis journal - experimental, translational and clinical 20220401 2

<h4>Background</h4>Multiple sclerosis (MS) has been associated with increased mortality ratios, but few studies have investigated the independent association of MS with mortality.<h4>Objective</h4>To examine the prospective association of MS with risk of mortality in a nationally representative sample of U.S. adults.<h4>Methods</h4>This prospective study included 23,053 adults aged 45-79 years who participated in the National Health Interview Survey in 2002 and 2008. Physician-diagnosed MS was r ...[more]

PMID: 35665135

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Project description:BackgroundAdiposity predicts health outcomes, but this relationship could depend on population characteristics and adiposity indicator employed. In a representative sample of 11,437 US adults (National Health and Nutrition Examination Survey, 1988-1994, ages 18-64) we estimated associations with all-cause mortality for body mass index (BMI) and four abdominal adiposity indicators (waist circumference [WC], waist-to-height ratio [WHtR], waist-to-hip ratio [WHR], and waist-to-thigh ratio [WTR]). In a fasting subsample we considered the lipid accumulation product (LAP; [WC enlargement*triglycerides]).Methods and findingsFor each adiposity indicator we estimated linear and categorical mortality risks using sex-specific, proportional-hazards models adjusted for age, black ancestry, tobacco exposure, and socioeconomic position. There were 1,081 deaths through 2006. Using linear models we found little difference among indicators (adjusted hazard ratios [aHRs] per SD increase 1.2-1.4 for men, 1.3-1.5 for women). Using categorical models, men in adiposity midrange (quartiles 2+3; compared to quartile 1) were not at significantly increased risk (aHRs<1.1) unless assessed by WTR (aHR 1.4 [95%CI 1.0-1.9]). Women in adiposity midrange, however, tended toward elevated risk (aHRs 1.2-1.5), except for black women assessed by BMI, WC or WHtR (aHRs 0.7-0.8). Men or women in adiposity quartile 4 (compared to midrange) were generally at risk (aHRs>1.1), especially black men assessed by WTR (aHR 1.9 [1.4-2.6]) and black women by LAP (aHR 2.2 [1.4-3.5]). Quartile 4 of WC or WHtR carried no significant risk for diabetic persons (aHRs 0.7-1.1), but elevated risks for those without diabetes (aHRs>1.5). For both sexes, quartile 4 of LAP carried increased risks for tobacco-exposed persons (aHRs>1.6) but not for non-exposed (aHRs<1.0).ConclusionsPredictions of mortality risk associated with top-quartile adiposity vary with the indicator used, sex, ancestry, and other characteristics. Interpretations of adiposity should consider how variation in the physiology and expandability of regional adipose-tissue depots impacts health.

Dataset Information

Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States.

Background

Objective

Methods

Results

Conclusion

Publications

Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States.

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