Synthesis of microporous hydrogen-bonded supramolecular organic frameworks through guanosine self-assembly.

ABSTRACT: Extending the structural hierarchy and complexity through small-molecular self-assembly is a powerful way to obtain large discrete, functional molecular architecture. A hydrogen-bonded supramolecular organic framework (H_SOF) with nanometer-size pores is constructed in a solid state with simple guanosine-monomer self-assembly. To extend the hierarchy of the G-quartet self-assembly to a higher order thanthatofthetraditionalG-quadruplex,H-bondacceptorsontheC-8 position of guanosine are introduced to establish inter-quadruplex linkage via H bonding to N(2)-H_B from the neighboring G-quartet. After screening different C-8 substitution groups and various synthesis conditions, H_SOF-G1a' is obtained by solvent evaporation under diluted condition. Single-crystal X-ray structure reveals that cubic repeating units formed by G₈ are the supermolecule secondary building block (SBU) with large pores (d=34A). To our knowledge, this is the first G-quartet self-assembly with an organized structure beyond cylindrical G-quadruplexes.

SUBMITTER: He Y 

PROVIDER: S-EPMC9162061 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature