Ontology highlight
ABSTRACT:
SUBMITTER: Wu JJ
PROVIDER: S-EPMC9167818 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Wu Jun-Jie JJ Sun Zi-Li ZL Liu Si-Yu SY Chen Zhong-Hua ZH Yuan Zheng-Dong ZD Zou Ming-Li ML Teng Ying-Ying YY Li Yue-Yue YY Guo Dan-Yang DY Yuan Feng-Lai FL
Cell death & disease 20220606 6
Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the inflammatory process. Acid-sensing ion channels (ASICs) are ligand-gated ion channels on the cell membrane that sense the drop in extracellular pH. The molecular mechanisms by which skin fibroblasts are regulated by acid-sensing ion channel 3 (ASIC3) remain unknown. This study investigated w ...[more]