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The miR-124-p63 feedback loop modulates colorectal cancer growth.

ABSTRACT: Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ?Np63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. Taken together, these results reveal a feedback loop between miRNAs and TFs. This feedback loop comprises miR-124, iASPP, STAT1, miR-155, TAp63 and ?Np63, which are essential for CRC growth. Moreover, this feedback loop is perturbed in human colon carcinomas, which suggests that the manipulation of this microRNA-TF feedback loop has therapeutic potential for CRC.

SUBMITTER: Liu K

PROVIDER: S-EPMC5438716 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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The miR-124-p63 feedback loop modulates colorectal cancer growth.

Liu Kuijie K Yao Hongliang H Lei Sanlin S Xiong Li L Qi Haizhi H Qian Ke K Liu Jiqiang J Wang Peng P Zhao Hua H

Oncotarget 20170401 17

Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a re ...[more]

PMID: 28418858

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