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Spherical nucleic acids as an infectious disease vaccine platform.

ABSTRACT: SignificanceUsing SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure-function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can be rapidly employed to target COVID-19 through incorporation of the receptor-binding domain, and that the resulting vaccine potently activates human cells in vitro and mice in vivo. Furthermore, when challenged with a lethal viral infection, only mice treated with the SNA vaccine survived. Taken together, this work underscores the importance of rational vaccine design for infectious disease to yield vaccines that elicit more potent immune responses to effectively fight disease.

SUBMITTER: Teplensky MH

PROVIDER: S-EPMC9168922 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Spherical nucleic acids as an infectious disease vaccine platform.

Teplensky Michelle H MH Distler Max E ME Kusmierz Caroline D CD Evangelopoulos Michael M Gula Haley H Elli Derek D Tomatsidou Anastasia A Nicolaescu Vlad V Gelarden Ian I Yeldandi Anjana A Batlle Daniel D Missiakas Dominique D Mirkin Chad A CA

Proceedings of the National Academy of Sciences of the United States of America 20220321 14

SignificanceUsing SARS-CoV-2 as a relevant case study for infectious disease, we investigate the structure-function relationships that dictate antiviral spherical nucleic acid (SNA) vaccine efficacy. We show that the SNA architecture can be rapidly employed to target COVID-19 through incorporation of the receptor-binding domain, and that the resulting vaccine potently activates human cells in vitro and mice in vivo. Furthermore, when challenged with a lethal viral infection, only mice treated wi ...[more]

PMID: 35312341

Dataset Information

Spherical nucleic acids as an infectious disease vaccine platform.

Publications

Spherical nucleic acids as an infectious disease vaccine platform.

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