Dataset Information

Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study.

ABSTRACT:

Background

Although patients with psoriasis have an increased risk of cancers, little is known about the risk of psoriasis in cancer patients.

Objective

We aimed to comparatively analyze the incidence and risk factors of psoriasis in gastric cancer patients who underwent gastrectomy and in the general population.

Methods

A nationwide retrospective cohort of 52,608 gastric cancer survivors (2007~2015) was compared to 123,438 matched controls from the general population to estimate the incidence and hazard ratio (HR) of new-onset psoriasis. We also calculated the HRs for psoriasis according to adjuvant cancer treatment, obesity, and vitamin B₁₂ supplementation in gastric cancer survivors.

Results

During a mean follow-up of 6.85 years, 645 of the 52,608 gastric cancer patients developed psoriasis, while 1,806 in the 123,438 matched control group developed psoriasis. Gastric cancer patients had a decreased risk of psoriasis (HR, 0.86; 95% confidence interval, 0.79~0.94), especially those who underwent subtotal gastrectomy. We found that vitamin B₁₂ supplementation for more than 3 years had an additive effect on decreasing the risk of psoriasis in gastric cancer patients who underwent subtotal gastrectomy. Total gastrectomy, radio/chemotherapy, and obesity did not affect the risk of psoriasis in gastric cancer survivors.

Conclusion

The incidence of psoriasis is slightly lower in gastric cancer survivors than in the general population. Our results suggest that the development of psoriasis may be reduced by removing the source of systemic inflammation caused by Helicobacter pylori infection through subtotal gastrectomy in gastric cancer survivors.

SUBMITTER: Kim BR

PROVIDER: S-EPMC9171185 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study.

Kim Bo Ri BR Lee Dong Ho DH Shim Hyun Ik HI Kim Jee Woo JW Park Sanghyun S Shin Cheol Min CM Han Kyungdo K Youn Sang Woong SW

Annals of dermatology 20220520 3

<h4>Background</h4>Although patients with psoriasis have an increased risk of cancers, little is known about the risk of psoriasis in cancer patients.<h4>Objective</h4>We aimed to comparatively analyze the incidence and risk factors of psoriasis in gastric cancer patients who underwent gastrectomy and in the general population.<h4>Methods</h4>A nationwide retrospective cohort of 52,608 gastric cancer survivors (2007~2015) was compared to 123,438 matched controls from the general population to es ...[more]

PMID: 35721330

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Dataset Information

Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study.

Background

Objective

Methods

Results

Conclusion

Publications

Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study.

Similar Datasets

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