Dataset Information

Hinge point emergence in mammalian spinal neurulation.

ABSTRACT: Neurulation is the process in early vertebrate embryonic development during which the neural plate folds to form the neural tube. Spinal neural tube folding in the posterior neuropore changes over time, first showing a median hinge point, then both the median hinge point and dorsolateral hinge points, followed by dorsolateral hinge points only. The biomechanical mechanism of hinge point formation in the mammalian neural tube is poorly understood. Here we employ a mechanical finite element model to study neural tube formation. The computational model mimics the mammalian neural tube using microscopy data from mouse and human embryos. While intrinsic curvature at the neural plate midline has been hypothesized to drive neural tube folding, intrinsic curvature was not sufficient for tube closure in our simulations. We achieved neural tube closure with an alternative model combining mesoderm expansion, nonneural ectoderm expansion, and neural plate adhesion to the notochord. Dorsolateral hinge points emerged in simulations with low mesoderm expansion and zippering. We propose that zippering provides the biomechanical force for dorsolateral hinge point formation in settings where the neural plate lateral sides extend above the mesoderm. Together, these results provide a perspective on the biomechanical and molecular mechanism of mammalian spinal neurulation.

SUBMITTER: de Goederen V

PROVIDER: S-EPMC9172135 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Hinge point emergence in mammalian spinal neurulation.

de Goederen Veerle V Vetter Roman R McDole Katie K Iber Dagmar D

Proceedings of the National Academy of Sciences of the United States of America 20220513 20

Neurulation is the process in early vertebrate embryonic development during which the neural plate folds to form the neural tube. Spinal neural tube folding in the posterior neuropore changes over time, first showing a median hinge point, then both the median hinge point and dorsolateral hinge points, followed by dorsolateral hinge points only. The biomechanical mechanism of hinge point formation in the mammalian neural tube is poorly understood. Here we employ a mechanical finite element model ...[more]

PMID: 35561223

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Project description:BackgroundPreoperative deformity and hinge position are associated with the magnitude of the gap opening during corrective osteotomy. A larger opening gap angle is associated with a higher risk of complications. This cross-sectional study sought to identify a suitable hinge position that results in the smallest opening angle during tibial condylar valgus osteotomy (TCVO).MethodsThe data of 66 arthritic knees treated by TCVO were included, comprising 16 knees with the hinge points selected medial to the center (group M), 21 knees with the hinge points selected at the center (group C), and 29 knees with the hinge points selected lateral to the center of the intercondylar eminence (group L). The opening gap angles and the correction amounts of the medial proximal tibial angle (ΔMPTA) were compared among the 3 groups to identify the preliminary relationship between the hinge positions and the opening gap angle. A simplified geometric model with the hinge positions selected at the medial beak, the center, and the lateral beak of the intercondylar eminence was constructed to simulate the realignment process. Several anatomical points were allocated as Cartesian coordinates. The opening gap angle with different hinge positions was mathematically formulated with MATLAB (MathWorks, Natick, MA, USA).ResultsThe average ΔMPTAs were 9.4±2.9°, 9.4±3.5°, and 9.3±3.0° in groups L, C, and M, respectively. The opening angle of the osteotomy gap was the largest in group M and the smallest in group L (29.7±11.1° and 16.9±5.3°; P<0.01). The comparison of the opening angle per the ΔMPTA revealed a similar pattern. The simulated realignment process indicated that the hinge point at the lateral beak of the intercondylar eminence led to the smallest opening angle. The opening angle during TCVO was mathematically derived in terms of the ΔMPTA, the position of the intersection of the pre- and postoperative joint lines, and the position of the hinge point.ConclusionsThe hinge point at the lateral beak of the intercondylar eminence results in the smallest opening angle and may be suitable for TCVO.

Dataset Information

Hinge point emergence in mammalian spinal neurulation.

Publications

Hinge point emergence in mammalian spinal neurulation.

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