Fluorescent PARP Inhibitors Applied To Intracranial Glioblastoma: Accumulation and Persistence In Vivo.
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ABSTRACT:
SUBMITTER: Gao Z
PROVIDER: S-EPMC9190034 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Fluorescent PARP Inhibitors Applied To Intracranial Glioblastoma: Accumulation and Persistence In Vivo.
Gao Zhe Z Yang Zhen Z Li Zheng Z Burgess Kevin K
ACS medicinal chemistry letters 20220506 6
Rucaparib-containing fluorescent probes (<b>1</b>-<b>3</b>) inhibit PARP1 in cell models. One of these (<b>1</b>) was tested in a murine model and shown to permeate into implanted intracranial glioblastoma tumors and persist there for at least 24 h. ...[more]
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