Ontology highlight
ABSTRACT:
SUBMITTER: Basu I
PROVIDER: S-EPMC9200866 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Basu Ipsita I Gorai Biswajit B Chandran Thyageshwar T Maiti Prabal K PK Hussain Tanweer T
Communications biology 20220615 1
Accurate and high-speed scanning and subsequent selection of the correct start codon are important events in protein synthesis. Eukaryotic mRNAs have long 5' UTRs that are inspected for the presence of a start codon by the ribosomal 48S pre-initiation complex (PIC). However, the conformational state of the 48S PIC required for inspecting every codon is not clearly understood. Here, atomistic molecular dynamics (MD) simulations and energy calculations suggest that the scanning conformation of 48S ...[more]