Ontology highlight
ABSTRACT:
SUBMITTER: Loughran G
PROVIDER: S-EPMC3326321 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Loughran Gary G Sachs Matthew S MS Atkins John F JF Ivanov Ivaylo P IP Ivanov Ivaylo P IP
Nucleic acids research 20111207 7
An AUG in an optimal nucleotide context is the preferred translation initiation site in eukaryotic cells. Interactions among translation initiation factors, including eIF1 and eIF5, govern start codon selection. Experiments described here showed that high intracellular eIF5 levels reduced the stringency of start codon selection in human cells. In contrast, high intracellular eIF1 levels increased stringency. High levels of eIF5 induced translation of inhibitory upstream open reading frames (uORF ...[more]