Dataset Information

The relationship between P16^INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

ABSTRACT: DNA methylation can regulate the expression of tumour suppressor genes P16 and TP53, environmental factors, which are both important factors related to an increased risk and prognosis of oesophageal cancer (EC). However, the association between these two genes methylation status, as well as the effects of gene-environment interactions, EC risk remains unclear. A Hospital-based case-control study data were collected from 105 new EC cases and 108 controls. Promoter methylation status was investigated for P16 and TP53 genes using methylation-specific polymerase (MSP) chain reaction methods with SYBR green. Logistic and Cox regression models were used to analyse the association of P16 and TP53 promotor methylation status with EC risk and prognosis, respectively. Our results suggest P16, TP53 methylation significantly increased the risk of EC (OR = 5.24, 95% CI: 2.57-10.66, P < 0.001; OR = 3.38, 95% CI: 1.17-6.67, P < 0.001, respectively). In addition, P16 and TP53 promoter methylation status and the combined effects between environmental factors and its methylations in tissue were correlated with the EC risk and prognosis of EC patients. As a new biomarker, the methylation of P16 and TP53 can serve as a potential predictive biomarker of EC.

SUBMITTER: Poosari A

PROVIDER: S-EPMC9209525 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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The relationship between P16<sup>INK4A</sup> and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

Poosari Arisara A Nutravong Thitima T Namwat Wises W Wasenang Wiphawan W Sa-Ngiamwibool Prakasit P Ungareewittaya Piti P

Scientific reports 20220620 1

DNA methylation can regulate the expression of tumour suppressor genes P16 and TP53, environmental factors, which are both important factors related to an increased risk and prognosis of oesophageal cancer (EC). However, the association between these two genes methylation status, as well as the effects of gene-environment interactions, EC risk remains unclear. A Hospital-based case-control study data were collected from 105 new EC cases and 108 controls. Promoter methylation status was investiga ...[more]

PMID: 35725923

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Dataset Information

The relationship between P16^INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

Publications

The relationship between P16<sup>INK4A</sup> and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

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Dataset Information

The relationship between P16INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

Publications

The relationship between P16<sup>INK4A</sup> and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The relationship between P16^INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand.