A meta-analysis of the relationship between RARβ gene promoter methylation and non-small cell lung cancer.

ABSTRACT:

Background

Hypermethylation of CpG islands in tumor suppressor gene plays an important role in carcinogenesis. Many studies have demonstrated that hypermethylation in promoter region of RARβ gene could be found with high prevalence in tumor tissue and autologous controls such as corresponding non-tumor lung tissue, sputum and plasma of the NSCLC patients. But with the small number subjects included in the individual studie, the statistical power is limited. Accordingly, we performed this meta-analysis to further asses the relationship of methylation prevalence between the cancer tissue and atuologous controls (corresponding non-tumor lung tissue, sputum and plasma).

Methods

The published articles about RARβ gene promoter hypermethyltion were identified using a systematic sea

SUBMITTER: Hua F 

PROVIDER: S-EPMC4010458 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature