Immunity gene <i>IFITM3</i> variant: Relation to cognition and Alzheimer's disease pathology.

ABSTRACT:

Introduction

We investigated single-nucleotide polymorphisms (SNPs) in IFITM3, an innate immunity gene and modulator of amyloid beta in Alzheimer's disease (AD), for association with cognition and AD biomarkers.

Methods

We used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 1565) and AddNeuroMed (N = 633) as discovery and replication samples, respectively. We performed gene-based association analysis of SNPs in IFITM3 with cognitive performance and SNP-based association analysis with cognitive decline and amyloid, tau, and neurodegeneration biomarkers for AD.

Results

Gene-based association analysis showed that IFITM3 was significantly associated with cognitive performance. Particularly, rs10751647 in IFITM3</

SUBMITTER: Pyun JM 

PROVIDER: S-EPMC9212215 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature