Ontology highlight
ABSTRACT:
SUBMITTER: Cebrero-Cangueiro T
PROVIDER: S-EPMC9214247 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Cebrero-Cangueiro Tania T Labrador-Herrera Gema G Carretero-Ledesma Marta M Herrera-Espejo Soraya S Álvarez-Marín Rocío R Pachón Jerónimo J Cisneros José Miguel JM Pachón-Ibáñez María Eugenia ME
Life science alliance 20220621 10
We evaluated the efficacy of ceftazidime or colistin in combination with polyclonal IgM-enriched immunoglobulin (IgM-IG), in an experimental pneumonia model (C57BL/6J male mice) using two multidrug-resistant <i>Pseudomonas aeruginosa</i> strains, both ceftazidime-susceptible and one colistin-resistant. Pharmacodynamically optimised antimicrobials were administered for 72 h, and intravenous IgM-IG was given as a single dose. Bacterial tissues count and the mortality were analysed. Ceftazidime was ...[more]