Clinical Values of the Identified Hub Genes in Systemic Lupus Erythematosus.

ABSTRACT:

Objective

This study was conducted to identify the biomarkers and mechanisms associated with systemic lupus erythematosus(SLE) at a transcriptome level.

Methods

Microarray datasets were downloaded, and differentially expressed genes (DEGs) were identified. Enrichment and protein-protein interaction networks were analyzed, and hub genes were discovered. The levels of top 10 hub genes were validated by another dataset. The diagnostic accuracy of the hub genes was evaluated with the area under the curve of the receiver operating characteristic curve (ROC-AUC). The odds ratios (OR) and 95% confidence intervals (CI) of the relationship between clinical manifestations and hub genes were estimated with multivariable logistic regression. The relationships between the expression leve

SUBMITTER: Xiao L 

PROVIDER: S-EPMC9219551 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature