Ontology highlight
ABSTRACT: Systematic review registration
PROSPERO, identifier CRD42022306558.
SUBMITTER: Thawley AJ
PROVIDER: S-EPMC9226456 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Thawley Alexandra Jade AJ Veneziani Luciana Peixoto LP Rabelo-da-Ponte Francisco Diego FD Riederer Ingo I Mendes-da-Cruz Daniella Areas DA Bambini-Junior Victorio V
Frontiers in immunology 20220610
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the pre ...[more]