IgG N-glycome changes during the course of severe COVID-19: An observational study.

ABSTRACT:

Background

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the main global health problems since 2019. Glycans attached to the Fc portion of immunoglobulin G (IgG) are important modulators of IgG effector functions. Fc region binds to different receptors on the surface of various immune cells, dictating the type of immune response. Here, we performed a large longitudinal study to determine whether the severity and duration of COVID-19 are associated with altered IgG glycosylation.

Methods

Using ultra-high-performance liquid chromatography analysis of released glycans, we analysed the composition of the total IgG N-glycome longitudinally during COVID-19 from four independe

SUBMITTER: Petrovic T 

PROVIDER: S-EPMC9234382 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature