Dataset Information

In-hospital mortality in SARS-CoV-2 stratified by the use of corticosteroid.

ABSTRACT:

Objective

To investigate COVID-19 related mоrtаlity according to the use of corticosteroid therapy.

Design

Retrospective cohort study.

Setting

Two tertiary hospitals in Kuwait.

Participants

Overall, 962 patients with confirmed SARS-CoV-2 infection, were stratified according to whether they were treated with corticosteroids (dexamethasone or methylprednisolone). The mean age of the patients was 50.2 ± 15.9 years and 344/962 (35.9%) were female.

Main outcome measures

In-hospital mortality and cumulative all-cause mortality.

Results

Compared to non-corticosteroid therapy patients, corticosteroid therapy patients had a higher prevalence of hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease, and chronic kidney disease; a longer hospital stay (median [IQR]: 17.0 [5.0-57.3] days vs 14.0 [2.0-50.2] days); and a higher in-hospital mortality (51/199 [25.6%] vs 36/763 [4.7%]). Logistic regression analysis showed a higher in-hospital mortality in the corticosteroid group (adjusted odds ratio [aOR]: 4.57, 95% confidence interval [CI]: 2.64-8.02, p < 0.001). Cox proportional hazards regression showed that corticosteroid use was a significant predictor of mortality (hazard ratio [HR]: 3.96, p < 0.001).

Conclusions

In-hospital mortality in patients with SARS-CoV-2 on corticosteroid therapy was 4.6 times higher than in those without corticosteroid therapy.

SUBMITTER: Alotaibi N

PROVIDER: S-EPMC9239918 | biostudies-literature |

REPOSITORIES: biostudies-literature

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