Ontology highlight
ABSTRACT:
SUBMITTER: Navarro-Paya C
PROVIDER: S-EPMC9240306 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Navarro-Paya Carlos C Sanz-Hernandez Maximo M De Simone Alfonso A
Frontiers in molecular biosciences 20220615
Membrane binding by α-synuclein (αS), an intrinsically disordered protein whose aggregation is associated with Parkinson's disease, is a key step in determining its biological properties under both physiological and pathological conditions. Upon membrane interaction, αS retains a partial level of structural disorder despite acquiring α-helical content. In the membrane-bound state, the equilibrium between the helical-bound and disordered-detached states of the central region of αS (residues 65-97 ...[more]