Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC9245005 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Cell reports. Medicine 20220609 6
Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8<sup>+</sup> T cell antitumor activity. Although innate natural killer (NK) cells are triggered by loss of MHC class I, their response is often inadequate. To increase tumor susceptibility to both innate and adaptive immune elimination, we performed parallel genome-wide CRISPR-Cas9 knockout screens under NK and CD8<sup>+</sup> T cell pressure. We identify all components, RNF31, RBCK1, ...[more]