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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

ABSTRACT: We evaluated whether there are transcriptional differences between RNF31-proficient immune-resistant and RNF31-deficient immune-sensitive tumor cells. We stimulated sensitive (sgRNF31- or HOIPIN-8-treated) and resistant (sgCtl, vehicle) BLM tumor cells with TNF for 0 or 6 hours and performed RNA sequencing analysis. Tumor cells sensitized by RNF31 inhibition show a reduced canonical NF-kB and increased pro-death signature upon TNF challenge.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186396 | GEO | 2022/05/14

REPOSITORIES: GEO

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

Project description:RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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